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Xenical uses a fat blocking mode of action that works in the stomach. Dietary fats are large molecules that must be broken down by enzymes, called lipases, before they can be absorbed into the bloodstream. When taken with meals, Xenical attaches to the lipases and blocks them from breaking down the fat in the diet.

 

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*Xenical works here, covalently bonding to the pancreatic lipases, preventing calories from being absorbed.

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